Dissociatives The Big & Dandy 3-MeO-PCE Thread

[DroneLore]

I ate 28mg tonight (technically I let the vast majority of it linger in my mouth for 10 - 15 minutes before swallowing so it was also kinda sublingual) plus a little bit that was left over from the night before.... and then I smoked some. Got into a pretty comfy, warm, dissociated state. I think I may have been overestimating this compounds potency.

In the interest of harm reduction I should mention that I have been doing dissociatives more consistently than I have at any other point in my life. As a result, my tolerance is higher than it's ever been. I have been regularly consuming 20+mg of O-PCE daily. I've noticed the intensity of the experiences diminishing even as the doses continue to increase.

 

[belligerent drunk]

Exactly how potent is this compound? If someone could give it to me in terms of 2'-Oxo-PCE, that'd great. So like how many mg of O-PCE equals approx 20mg of 3-MeO-PCE. I've read that the latter is significantly more potent, I've also read they are more or less equipotent. I'd like to get a straight answer.

I've done a total of about 4 g O-PCE and 2 g 3-MeO-PCE with oral, nasal, and rectal ROAs, and in my experience they're roughly equipotent. Even effect-wise, they're very damn similar IME. If I'd been using either for days, and you gave me a dose and asked which one it was, apart from onset time, I wouldn't be able to tell.

That said, sometimes it feels like 3-MeO-PCE is "milder" in its effects, and I can tolerate a slightly higher dose, to the point where 25 mg 3MeO is about equivalent to 20 mg O-PCE.

 

[MSK]

I've done a total of about 4 g O-PCE and 2 g 3-MeO-PCE with oral, nasal, and rectal ROAs, and in my experience they're roughly equipotent. Even effect-wise, they're very damn similar IME. If I'd been using either for days, and you gave me a dose and asked which one it was, apart from onset time, I wouldn't be able to tell.

That said, sometimes it feels like 3-MeO-PCE is "milder" in its effects, and I can tolerate a slightly higher dose, to the point where 25 mg 3MeO is about equivalent to 20 mg O-PCE.

They are really different on medium/high doses. 3-MeO-PCE is more stimmy and fuctional without nearly any hole potential, while 2-OxO-PCE is kinda more sedating with the higher hole potential I've seen in any disso to this point, ketamine included.

 

[Ziiirp]

They are really different on medium/high doses. 3-MeO-PCE is more stimmy and fuctional without nearly any hole potential, while 2-OxO-PCE is kinda more sedating with the higher hole potential I've seen in any disso to this point, ketamine included.

I agree, at least via nasal ROA the effects are very different qualitatively. 2-Oxo-PCE easily leads to a hole even after 20 mg insufflated. 3-Meo-PCE rather stims you (orally it is more sedating) up a little at that dose and may make you manic with only slight motor impairment and nearly full consciousness.

 

[belligerent drunk]

Strange then. I definitely have explored the high doses (20 mg rectal every 2 hours for ca 20 hours), but can't say I noticed that much of a difference between the two.

 

[Rantanplan]

I like this one, but on the other hand, I am missing a little bit the holing/manic thing like with MXE.

Can also confirm that, snorting gives you good simulating feel.
Mostly I combine it with beer, with it is a good combination. It also well combines with Piracetam.

I am asking myself at the moment, that if it is possible to add the Oxo again, so it will convert to MXE?

 

[Hexagon Sun]

Wouldn´t racetams block the disso effects?

To add the oxo you need something like a big lab, tons of other compounds and a degree in alchemy

 

[nepalnt21]

according to the skeletal structure depicted on the psychonaut wiki 3-MeO-PCE article, this compound has two stereocenters. if this is true, i assume most batches are going to be a 25-25-25-25% mixture of each isomer, correct? would resolving the isomers be a futile effort?

 

[Xorkoth]

Wow, really? 3-MeO-PCP has no stereocenters, does this really have 2? If so, then unless people are all taking the same route, there should be a large potential for batch variance.

 

[vortech]

Only encountered 2 batches but they were quite different in effect and appearance.

 

[Rantanplan]

Wouldn´t racetams block the disso effects?

Why should they? I am unsure. Because I took everyday Piracetam (mostly 2.4g / sometimes 3.6), for 11 months now.
May be the should try it alone?

To add the oxo you need something like a big lab, tons of other compounds and a degree in alchemy

I asked because I read somewhere that some are converting there RCs into better forms. And I am still missing MXE. My favorite of all time.

 

[Morninggloryseed]

3-meo-pce has no stereocenters. O-pce has one, and can be resolved into two stereoisomers in the manor of ketamine.

 

[Hexagon Sun]

Why should they? I am unsure. Because I took everyday Piracetam (mostly 2.4g / sometimes 3.6), for 11 months now.
May be the should try it alone?


I asked because I read somewhere that some are converting there RCs into better forms. And I am still missing MXE. My favorite of all time.

I guess what you mean is people converting bases to salts and viceversa, which is something you can do in your kitchen with tons of RCs. That way you can do an RC more smokable-friendly or more sniffable-friendly, for example, but the nature of the compound is the same.

I understand what you mean, MXE is one of my top 3 too, such a delicious compound... I hope it will appear again in a not so distant future. However, adding a OXO group is near impossible without the lab, the knowledge and the additional compounds. Our only hope is to wait or to custom order it.

Regarding racetams, im almost positive that somehow they block the disso effects, but I should do some research to reassure it

Edit:

Piracetam and the other *racetams are like anti-dissociatives in terms of action, FYI. I'm pretty sure Jamshyd said that the *racetams are basically antidotes for ketamine, and kill the dissociatiev action. This doesn't bode well for a *racetam+MXE combo.

http://www.bluelight.org/vb/threads/557882-Piracetam-and-Methoxetamine-(MXE)

 

[Incunabula]

It's well known that racetams and other nootropics, block or dampen the effects of dissociatives. Google is your freind.

 

[dreamofrc]

Does anyone know if this is affected by stuff that inhibits or competes for CYP3A4 or CYP2D6 enzymes the way some other dissos (or drugs in general) do?

Btw it is definitely possible to hole on this but I'm not sure it's advisable. I holed hard my very first time with it but the comeup/comedown periods I felt as close to going "insane" as I have with any drug and I took 40mg total which a lot more than the recommended "heavy dose". Once I was in the hole I was completely immobilized though, but with some absolutely crazy thoughts and mind states that are hard to even describe since I was sort of no longer human at that point.

At lower doses it's one of my all time favorite drugs. It has really great euphoria for me that is actually reminiscent of MDMA in some ways, but with comfy disso numbness and more "out there" thoughts. Some significant loss of motor skills too but not to the extent of many other dissos. I've gone on a few walks out in the woods without much issue, other than the giant crazy grin on my face.

 

[treezy z]

You can definitely hole but some craziness involved. I ate 160mg and spent some weeks in a psych ward.

 

[iamtypo]

Are there any risks of combining normal doses of 3-meo-pce with 4-aco-met? I did this the other week and it was quite simply amazing. Serotonin syndrome - any risk? I did not get any adverse effect. But after reading about the death of MXE+MDAI I started wondering of these sort of combos. Seems like other people have tried it without issues, too, but that doesn’t mean it’s completely safe. Also what about 3-meo-pce and buprenorphine?

 

[vortech]

Not risk of SS to combine as I understand it. Sounds like a great combo in my opinion! Just don't go overboard with doses or frequency and it should remain a light experience.

Their shouldn't be an issue combining with buprenorphine either. With personal experience with the combination, I judged it to be just fine.

 

[MSK]

Disso + psychedelic is the best combo ever. It feels and should be pretty safe too if you don't push up dosages so don't worries there, you just discovered the drug holy grial

 

[Vediog]

Most tryptamines don't release serotonin, they mimic it and activate certain serotonin receptors. I think AMT might be an exception.

I haven't tried 3-meo-pce, but rather its sister compound 3-meo-pcp, but every time things went bad with that one was when combined with MDMA, so I would avoid serotonin releasers with these compounds regardless of serotonin syndrome.