25e came through my neck of the woods last year.
I wrote two trip reports on it;
http://www.bluelight.org/vb/threads/735724-(25E-NBOMe-250mcg)-First-time-Exploring-the-NBOMes
http://www.bluelight.org/vb/threads/735726-(25E-NBOMe-400mcg)-Second-Time-What-time-is-it
Thinking back on it I wish I really hadn't taken it, it was a novelty but over all I felt it to be a rather shallow and useless drug. Especially considering what it did to my tolerance and how it felt on my body. I never took it without having an upset stomach throughout the experience and on my last attempt at 450mcg or so it gave me internal pains. It felt _very_ bad in the body and the minimal effects weren't worth what I got out of it.
LSD is just an entirely different level of experience. It actually provides a proper trip, I think the visuals are better, and there isn't an overall feeling of anxiety based on the substance begin used. With LSD you always know the substance isn't going to cause death (unless you consume ungodly amounts that you'll probably never have access to). With the NBOMes you're always taking a risk and that will be at the forefront of your mind the entire time you're using them.
For what it's worth I know of many other people that consumed the same 25e that I did. Some of them using it in a very dangerous way by taking multiple redoses over several days and using it multiple weekends in a row. They eventually reported that it produced no effects other than stimulation, which is probably because of the rapid and heavy tolerance these substances cause. Almost every last one of them have since swore off of it and refuse to use it anymore.
I had one trip with it that I never wrote a trip report for. On that night I shared it with a close friend who was eager to try it. He is an opioid/benzo addict so going in I should have known better but...alas he's my friend and I didn't want to deny him. Anyway we dosed at about 250mcg and were enjoying it, about an hour in he wanted a re-dose which against my better judgement I allowed. When I gave him the nasal spray bottle he started going to town on it and I quickly snatched it away but not before he'd done 4 or more sprays. I honestly lost count...
Anyway he was okay and had a good time but I would no longer allow him access to the substance. During the trip he declared it was the best drug he'd ever done and that he could see himself quitting opioids and switching to it. He asked if I had anymore of it several times over the course of the next couple of months, and at one point I caught him searching for the bottle at my home during a large house party. He's obviously not allowed inside my home a lone any longer (I didn't know he'd gotten _that_ bad). I find this rather odd since I've never met anyone else that really cared for it. It was always one of those last resort type of substances for most of us locals.
I also know of two local fatalities caused by either 25e or 25i that was sold to a group of people as powder. I did not know anyone involved however I did know several people that were close to them and followed the local news about it. Someone sold them powder and either didn't explain what it was or they ignored his advice about how to prep it. A group of people eyeballed lines from the bag and snorted them. Two of them died and three lived after spending a few days in the hospital. I don't have much more information beyond that but I should probably collect it and send it off to erowid or something. It did make the local news so I can verify the story.