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Opioids Loperamide (Imodium) Megathread v. 2

http://www.ncbi.nlm.nih.gov/m/pubmed/16758263/?i=2&from=/11719726/related

Posted merely for the purpose of demonstrating that CYP3A4 inhibitors can exponentially increase plasma levels of loperamide, thus allowing you to use MUCH smaller doses for reducing opioid WD symptoms.

The usefulness in this is that the lower doses put less stress on your intestine, while delivering the same amount into the blood stream as a larger dose.

That is, taking say, 16mg with a (potent) inhibitor could yield the same PNS(and possibly mild CNS) effects as taking 64mg alone, but with only 1/4th the amount of intestinal activity.

(And what happened to that last post chastising us? Barely on topic is still on topic, right?)
 
I've looked through a bunch of this thread and maybe it's on the old one but all I could find at the store was the "multi symptom relief" immodium last time I used it I had to take like 8mg initially then one every three or four hours for relief for about a day and a half. Can you even take that much multi symptom? Just curious, not trying to die out here. And last time I got the normal sublingual kind not multi symptom.
 
You won't die, but you should ONLY BE TAKING PURE LOPERAMIDE. DO NOT take a product that has other active ingredients.

The only thing I've seen loperamide combined with is simethicone, which is a fairly benign substance, but you still don't need to be taking 10x the recommended amount.

But at those doses, you'll be fine. Hell, simethicone itself isn't deadly at any dose.

That is what is in your tablets, simethicone, right?
 
Yes, that stuff. So I can take more? I took 4 mg then 4 more mg and hour later and I know it take a while to kick in but I feel like shit. Id rather start with at least 12 mg. I was 21 days clean then someone handed me a dilaudid 8 like an hour after I happened to find a needle. Great high, but I feel like shit now, lol.
 
Did you read the first part of my post? You need to get pure loperamide tablets, it's cheap as hell, far cheaper than the "multi-symptom" tablets.

I wouldn't take much more. Honestly, the doses you need for relieving hydromorphone(dilaudid) WD will be unattainable with the simethicone tablets.

As I said though, simethicone isn't deadly, but nonetheless will cause very uncomfortable side effects at high doses.

Go ahead and take another 8mg if your miserable, but I doubt it will help. And it takes 3-4h to reach full effect, so keep that in mind.
 
Thanks. I read all your post ill wait it out then-- I know I need the other but I've got hours till a store opens that has them-- I went to all the open ones and it was just multi symptom. I feel like it will be more effective with this than full tilt withdrawal. No way my body is going to jump into that nonsense again. Thanks again!
 
If it's just rebound symptoms(IE, you are not actually physically dependent again) then loperamide might do more harm than good. Loperamide is only effective for REDUCING TRUE OPIOID WD SYMPTOMS, it isn't for fulfilling a void left by not having opioids.

But if you are having opioid WD, it will take a pretty high dose for any relief, 8mg IV dilaudid is far more powerful than any dose of loperamide.

Either way, I wish you luck, and read the last few pages of this thread for all the info you need.
 
Thanks I don't think I was dependent again I'm probably just being a pussy. It'll work out. Ill burn something when everyone wakes up. Thanks. I'm trying to look through the whole thread now.
 
Thanks-- I don't feel that bad right now. I know he said its just for full on withdrawal but I had body aches like a son of a bitch last night and sweats... Anxiety... I could finally sleep after taking that 8 mg once it kicked in 3 hours later. And I'm a dopehead not being able to shit kind of feels like a non- problem but I see that people are concerned about that on here. Everybody has different experiences. I'm up to 12 mg now and going to look for just loperamide here soon. Thanks everyone.
 
Thanks, loluhatzdrugs.


My current methadone dose is 140 mg (two 70 mg. tablets). In the methadone center doctor was explaining to me how it will be phasing out. From 140 mg. to 60 mg. down me 10 mg. biweekly. From 60 mg. to 10 mg. down me 2.5 mg biweekly and from 10 mg. until the full withdrawal down me 1 mg. biweekly. He told me that from 60 mg. to down starts the hard and from 10 mg. to down starts the worst. I've been at rehab centers and I've seen many people gradually abandoned methadone and although methadone offset is gradual withdrawal symptoms such as anxiety, insomnia, gastrointestinal discomfort, aching bones and muscles are presented. I can get without a prescription clonidine, clonidine would it be good to use until 60 mg. and then using loperamide?

Does omeprazole make loperamide cruze BBB? What dose of omeprazole and loperamide? If loperamide is mu receptor agonist and crosses the BBB, why not put you high?
 
^ Um, no, it doesn't. H2 antagonists/PPI's have some potential in that regard, but it is more complicated than that.

What do you mean, "2 70mg tablets???"

I mean, I have never heard of a 70mg tablet. Just the 5's, 10's and 40mg wafers.

And 1mg/ml solution, 5mg/ml solution, 10mg/ml solution...
 
Luxxx said:
I'm very special sir
Click to expand...

You most certainly are. This ^ post is useless, and the only other post you've made on this forum is unreadable. Take some time and write things using correct grammar (in English...) and dividing up multiple sentences into cohesive thoughts separated into their own paragraphs.
 
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